| 发明名称 |
Humanized Anti-CD4 Antibody With Immunosuppressive Properties |
| 摘要 |
A humanized antibody derived from mouse monoclonal anti-CD4 antibody B-F5 is able to activate CD25+CD4+ regulatory T cells and is useful for preparing immunosuppressive compositions. |
| 申请公布号 |
US2014220008(A1) |
申请公布日期 |
2014.08.07 |
| 申请号 |
US201414176485 |
申请日期 |
2014.02.10 |
| 申请人 |
BIOTEST AG |
发明人 |
Wijdenes John;Jonuleit Helmut |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A humanized anti-CD4 antibody which is a humanized version of a mouse monoclonal anti-CD4 antibody, wherein the mouse monoclonal anti-CD4 antibody comprises a Vh region having SEQ ID NO: 9 and a Vk region having SEQ ID NO: 10, and wherein the humanized anti-CD4 antibody further comprises an IgG1 constant domain. |
| 地址 |
Dreieich DE |
