发明名称 |
PREPARATION OF ALKYL 3-DIFLUOROMETHYL-1-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ESTER |
摘要 |
<p>The present disclosure provides a novel and economically advantageous process for preparation of compounds of Formula I, such as alkyl 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid ester. The process includes acidification of the sodium enolate of alkyl difluoroacetoacetate by carbonic acid generated in situ by reacting carbon dioxide with water. The disclosure also includes promoting the ring closure reaction in which alkyl 2-alkomethylene-4, 4-difluoro-3-oxobutyrate is reacted with methylhydrazine in two phase system with a weak base such as Na2CO3 or K2CO3.</p> |
申请公布号 |
WO2014120397(A1) |
申请公布日期 |
2014.08.07 |
申请号 |
WO2014US10634 |
申请日期 |
2014.01.08 |
申请人 |
KINGCHEM, LLC |
发明人 |
WANG, ZHEQING;WANG, ANGANG |
分类号 |
C07C67/313;C07C67/343;C07C69/732;C07C69/738 |
主分类号 |
C07C67/313 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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