RUTHENIUM CARBON MONOXIDE RELEASING MOLECULES AND USES THEREOF

摘要

The present invention provides novel ruthenium compounds of Formula (I): or salts, isomers, hydrates, or solvates thereof, or combinations thereof; wherein E, R1, R2, R3, R4, R5, X1, and X2 are as defined herein, and pharmaceutical compositions thereof. Also provided are methods of use and treatment. Such compounds have been found useful in the treatment of malaria infection. Such compounds may also be useful in the treatment of inflammatory conditions, such as acute lung injury and acute respiratory distress syndrome, which optionally may be associated with a malaria infection.;

主权项

1. A compound of Formula (I):or a salt, isomer, hydrate, or solvate thereof, or combination thereof;wherein:
E is —S— or —Se—; R1 is hydrogen or C1-6alkyl; each instance of R2, R3, R4, and R5 is, independently, hydrogen, a carbohydrate group, or an oxygen protecting group; and X1 and X2 are each independently halogen.