NOVEL COMPOSITION FOR PREVENTING OR TREATING HEPATITIS C VIRUS, REGULATING PHOSPHORYLATION OF REPLICASE

摘要

The present invention relates a novel composition for preventing or treating hepatitis C virus, regulating the phosphorylation of a replicase. More specifically, it is possible to prevent or treat hepatitis C using a novel PRK2 inhibitor discovered through structure modeling, and to prevent or treat hepatitis C, particularly, interferon-insensitive hepatitis C through coadministration of an Hsp90 inhibitor.

主权项

1. A composition for preventing or treating hepatitis C virus comprising a compound expressed by Chemical Formula 1 below: wherein in Chemical Formula 1, Ar1 represents aryl or nitrogen-containing heteroaryl having 5 to 24 carbon atoms, or a nitrogen-containing substituted heterocyclic having 3 to 12 carbon atoms, R1 represents alkyl having 1 to 10 carbon atoms substituted with —NH—(O)— or nitrile, and Ar2 represents cycloalkyl having 3 to 12 carbon atoms, a nitrogen-containing substituted heterocyclic having 3 to 12 carbon atoms, nitrogen-containing heteroaryl having 5 to 24 carbon atoms, heteroaryloxy containing at least one of oxygen, nitrogen, and sulfur atoms and having 5 to 24 carbon atoms substituted or unsubstituted with aryl having 5 to 24 carbon atoms, or aryl having 5 to 24 carbon atoms substituted with —NH—(O)—R2, and the R2 represents alkyl having 1 to 10 carbon atoms.