MEASUREMENT AND COMPARISON OF IMMUNE DIVERSITY BY HIGH-THROUGHPUT SEQUENCING
摘要
High-throughput long read sequencing is used to perform immunogenomic characterization of expressed antibody repertoires in the context of vaccination. Informatic analysis allows global characterizations of isotype distributions, determination of the lineage structure of the repertoire and measure age and antigen related mutational activity. Global analysis of the immune system's clonal structure provides direct insight into the effects of vaccination and provides a detailed molecular portrait of age-related effects.
申请公布号
WO2014121272(A2)
申请公布日期
2014.08.07
申请号
WO2014US14670
申请日期
2014.02.04
申请人
QUAKE, STEPHEN R.;WEINSTEIN, JOSHUA;JIANG, NING;FISHER, DANIEL S.
发明人
QUAKE, STEPHEN R.;WEINSTEIN, JOSHUA;JIANG, NING;FISHER, DANIEL S.