| 摘要 |
PROBLEM TO BE SOLVED: To provide, in part, oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist.SOLUTION: The opioid antagonist is included in a ratio to the opioid agonist to provide a combination drug product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination drug product provides at least a mildly negative, "aversive" experience in physically dependent drug addicts (e.g., precipitated abstinence syndrome). |
