DISEASE TREATMENT VIA ANTIMICROBIAL PEPTIDES OR THEIR INHIBITORS

摘要

Provided are methods for the treatment of disease and promotion of healing that include providing a therapeutically effective amount of a mammalian antimicrobial peptide (AMP) or analog thereof, in particular a cathelicidin or cathelicidin fragment or cathelicidin analog, thereby treating the disease in the subject in need thereof. Also provided are specific analogs or fragments of cathelicidin that function as agonists, as do endogenous cathelicidins, or as either dominant negatives or as inhibitors to endogenous cathelicidin or to other endogenous AMPs or that compete with pro-inflammatory agents or fragments of AMPs on cognate receptors without inducing disease.

主权项

1. A method for treating in a mammal a metabolic disease or disorder, selected from the group consisting of Type 2 diabetes, insulin resistance, hyperglycemia, metabolic syndrome, obesity, overweight, cardiovascular disease, dyslipidemia, and metabolic endotoxemia the method comprising administering to a subject in need thereof, a therapeutically effective amount of a cathelicidin peptide selected from mCRAMP (SEQ ID NO: 61) or LL-37 (SEQ ID NO: 14).