发明名称 |
PRETARGETED ACTIVATABLE CELL PENETRATING PEPTIDE WITH INTRACELLULARY RELEASEABLE PRODRUG |
摘要 |
<p>Disclosed herein, the invention pertains to methods and compositions that find use in treatment, diagnosis, prognosis and characterization of disease and disease samples based on the ability of a disease sample to cleave a MTS molecule of the present invention. The MTS molecules of the present invention have a formula as disclosed herein and wherein A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutamates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X and Y are linkers; P is a pre-targeting moiety; M is a macromolecular carrier; C is a detectable moiety; and T is a compound for delivery to a target, including for example a therapeutic compound.</p> |
申请公布号 |
WO2014120837(A2) |
申请公布日期 |
2014.08.07 |
申请号 |
WO2014US13687 |
申请日期 |
2014.01.29 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
SAVARIAR, ELAMPRAKASH, N.;CRISP, JESSICA;TSIEN, ROGER, Y. |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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