| 主权项 |
1. A compound having Formula I, its enantiomers, diastereoisomers, hydrates, solvates, crystal forms and individual isomers, tautomers or a pharmaceutically acceptable salt thereof: wherein: R1 is H; R2 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C3-8 cycloalkyl or is substituted or unsubstituted C3-8 cycloalkenyl; R5 is —S—, —S(O)—, or —S(O)2—; R6 is 4-chloro-2-fluorophenyl; R17 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN, C(O)R19, NR20R21 or hydroxyl; R18 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN, C(O)R22, NR23R24 or hydroxyl; R7 is H, halogen, CN, substituted or unsubstituted —OC1-6 alkyl, substituted or unsubstituted C1-6 alkyl or is substituted or unsubstituted C3-8 cycloalkyl; R8 is H, substituted or unsubstituted C1-6 alkyl, halogen, substituted or unsubstituted —OC1-6 alkyl, CN or hydroxyl; R19 is H, OH or substituted or unsubstituted C1-6 alkyl R20 is H or substituted or unsubstituted C1-6 alkyl; R21 is H or substituted or unsubstituted C1-6 alkyl; R22 is H, OH or substituted or unsubstituted C1-6 alkyl R23 is H or substituted or unsubstituted C1-6 alkyl; and R24 is H or substituted or unsubstituted C1-6 alkyl. |
