发明名称 |
METHODS AND COMPOSITIONS TO MODIFY THE IMMUNOGENICITY OF A VASCULARIZED ORGAN OR TISSUE |
摘要 |
Disclosed herein is an RGD-enriched solubilized extracellular matrix composition derived from endothelial cell culture that can be used to modify the immunogenicity or thrombogenicity of an organ intended for transplant. The RGD-enriched solubilized extracellular matrix composition is applied to the lumen of the vasculature of the organ, thereby placing a barrier between the antigens on the lumenal surfaces of the transplanted organ and the blood of the recipient. |
申请公布号 |
US2014220548(A1) |
申请公布日期 |
2014.08.07 |
申请号 |
US201314072311 |
申请日期 |
2013.11.05 |
申请人 |
Orgamend, Inc. |
发明人 |
BRASILE Lauren |
分类号 |
A01N1/02 |
主分类号 |
A01N1/02 |
代理机构 |
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代理人 |
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主权项 |
1. An Arg-Gly-Asp (RGD)-enriched solubilized extracellular matrix comprising extracellular matrix protein from cultured endothelial cells, wherein said protein in said matrix is in the amount of 1-5 mg/ml and has an RGD absorbance at 450 nm of 0.3 to 0.7, and wherein said extracellular matrix has a fragment size of less than 2 microns. |
地址 |
Albany NY US |