| 发明名称 |
LEVELS OF BCMA PROTEIN EXPRESSION ON B CELLS AND USE IN DIAGNOSTIC METHODS |
| 摘要 |
The present invention provides a method of measuring the levels of BCMA in a biological sample, specifically upon the B cell surface. The diagnostic assays are useful in predicting an individual's likelihood of developing or currently suffering from an autoimmune disease, such as SLE, and for methods for treating an individual clinically diagnosed with an autoimmune disease. This diagnostic test serves to predict a patient's likelihood to respond to a specific drug treatment, in particular treatment with BLyS antagonists, either singly or in combination with other immune suppressive drugs |
| 申请公布号 |
US2014220014(A1) |
申请公布日期 |
2014.08.07 |
| 申请号 |
US201414192911 |
申请日期 |
2014.02.28 |
| 申请人 |
University of Washington ;ZymoGenetics, Inc. |
发明人 |
Dillon Stacey R.;Gross Jane A.;Elkon Keith B. |
| 分类号 |
C07K16/24;G01N33/564;C07K14/705 |
主分类号 |
C07K16/24 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of detecting increased BCMA protein expression on the surface of B cells of an individual comprising:
measuring a first level of BCMA protein expression in a biological sample and comparing that level to a second level of BCMA protein expression present on the surface of B cells of a healthy individual and determining the first level is increased as compared to the second level, wherein said increased BCMA protein expression is associated with an autoimmune disease. |
| 地址 |
Seattle WA US |
