Synthetic Antibodies

摘要

Methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.

主权项

1. A composition, comprising:
(a) a first affinity element bound to a template nucleic acid strand; (b) a second affinity element bound to a complementary nucleic acid strand, wherein the first affinity element and the second affinity element non-competitively bind to a common target comprising polypeptides; wherein the template nucleic acid strand and the complementary nucleic acid strand are annealed via base pairing to form an assembly; wherein the first affinity element and the second affinity element are separated in the assembly; and wherein either the template nucleic acid strand, the complementary nucleic acid strand, or both, are bound to a surface of a substrate.