发明名称 |
ANTIBODIES COMPRISING CHIMERIC CONSTANT DOMAINS |
摘要 |
Antibodies, antigen-binding proteins and Fc-fusion proteins that comprise recombinant polypeptides containing a chimeric heavy chain constant region sequence are provided that bind to certain Fc receptors however have reduced effector functions. Methods of making constructs for expression of such chimeric Fc-containing antibodies, antigen-binding proteins and Fc-fusion proteins in cell systems, and methods of producing and isolating the chimeric Fc-containing proteins are provided. |
申请公布号 |
WO2014121087(A1) |
申请公布日期 |
2014.08.07 |
申请号 |
WO2014US14175 |
申请日期 |
2014.01.31 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
DAVIS, SAMUEL;SMITH, ERIC;PATEL, SUPRIYA;RAFIQUE, ASHIQUE |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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