MINIMALLY INVASIVE SURGERY, INCLUDING VASCULAR CLOSURE, AND ASSOCIATED SEALANTS

摘要

The use of tissue sealants to perform vascular closure procedures, and associated systems and articles, are generally described. Hemostatic agents and tissue sealants are routinely used to prevent excess blood loss and to reconstruct tissue during surgical repair. Fibrin glue was approved by the FDA in the 1990's and can be used to impart topical hemostasis, provide sealant properties that are suitable is some clinical applications, and promote tissue approximation. Fibrin glue mimics the final steps of the coagulation cascade. In the presence of thrombin, fibrinogen is converted to fibrin.