ENTERIC COATED NANOPARTICLES FOR ORAL VACCINE AND DRUG DELIVERY AND METHODS OF PRODUCTION AND USE THEREOF

摘要

Described herein are nanoparticle-based compositions, kits, methods and platforms for oral delivery of drugs and vaccines to professional APCs (PAPCs) in a subject's intestinal tract. The composition, kits, platforms and methods involve the combined use of MHC targeting peptides (e.g., PADRE, CLIP, etc.) with charged particles or charged polymers (e.g., positively-charged highly branched polymeric dendrimers) as vehicles for the gastrointestinal tract-targeted delivery of therapeutic agents such as drugs and vaccines.