SYSTEMS AND METHODS FOR LOCAL DRUG DELIVERY TO KIDNEYS

摘要

Drug-delivery systems for local drug delivery to kidneys and associated systems and methods are disclosed herein. One aspect of the present technology is directed to drug-delivery systems that include a physiological sensor, an implantable medical device, and a control module configured to communicate with the physiological sensor and to control delivery of a drug in response to a physiological parameter measured by the physiological sensor. The implantable medical device can be configured to be surgically implanted in a patient with a delivery opening at or near a renal capsule of a kidney of the patient. Suitable drugs for local delivery to a kidney can include diuretics, aldosterone antagonists, vasodilators, renin inhibitors, and combinations thereof. In some embodiments, local drug delivery to a kidney can be used to treat hypertension, heart failure, or another condition associated with renal activity.

主权项

1. A system comprising:
a physiological sensor; an implantable medical device including a reservoir configured to contain a drug and a catheter that includes a lumen extending between the reservoir and a delivery opening, wherein the implantable medical device is configured to be surgically implanted in a human patient with the delivery opening at or near a renal capsule of a kidney of the patient; and a control module configured to communicate with the physiological sensor and to control delivery of the drug through the delivery opening in response to a physiological parameter measured by the physiological sensor.