SYSTEM AND METHOD FOR DELIVERING PROTEASE INHIBITORS

摘要

The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“TA”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation. Next, the formulation along with fibrinogen and thrombin is applied to a wound site where an outer surface of the polymer microsphere degrades in a proteolytic environment to expose and release the incorporated protease inhibitor to the surrounding hydrogel or sealant or clot matrix at the wound site.

主权项

1. A system for delaying fibrinolytic degradation of a hydrogel or sealant at a surgical wound site in presence of fibrinogen and thrombin, the system comprising:
a.) a protease inhibitor; and b.) an injectable biodegradable microsphere which provides a sustained release mechanism of said protease inhibitor in a proteolytic environment.