VARIANTS OF HUMANIZED IMMUNOMODULATORY MONOCLONAL ANTIBODIES

摘要

The present invention relates to humanized monoclonal antibodies, pharmaceutical compositions that include the same, and use thereof for the treatment of a variety of indications, particularly cancer and immunodeficiency disorders. In particular, the present invention provides modified antibodies or fragments thereof having specific amino acid modifications compared to the humanized monoclonal immunomodulatory antibody termed hBAT-1.

主权项

1. An antibody or antigen binding fragment thereof comprising a light chain variable region selected from the group consisting of SEQ ID NO: 1, 2, 3, and 4, and a heavy chain variable region selected from the group consisting of SEQ ID NO: 5, 6, 7, 8, and 9, wherein the antibody or antigen binding fragment thereof comprises at least one amino acid substitution at a position selected from: Phe 97 and Phe 93 of the light chain variable region to Ala, Leu or Val, or a substitution of Trp 107 of the heavy chain variable region to Ala, Leu, Val or Tyr.