TARGETED DELIVERY OF PROTEINS ACROSS THE BLOOD-BRAIN BARRIER

摘要

Embodiments of the invention are directed to compositions comprising a peptide sequence, or a nucleic acid encoding the same, wherein the peptide sequence includes a receptor-binding region of apolipoprotein E (apoE), or a sequence variant or fragment thereof, for directing delivery of a given protein or therapeutic across the blood brain barrier. Embodiments of the invention are also directed to methods of using the compositions for treating or preventing a neurological disorder, disease, or symptom in a subject in need thereof.

主权项

1. A composition comprising a peptide sequence, the peptide sequence comprising a receptor-binding region of apolipoprotein E (apoE), or a sequence variant, fragment, or oligomer thereof, and a protein to be delivered across the blood-brain barrier (BBB), wherein the peptide sequence containing the receptor-binding region and the protein are expressed as a fusion protein.