DIFFERENTIATION MODULATING AGENTS AND USES THEREFOR

摘要

The present invention is directed to methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (FGF) signaling pathway, especially the FGF-1 or FGF-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions.

主权项

1. A method of treating obesity or conditions of localized increases in adipogenesis, comprising administering to a human patient in need of such treatment, an adipogenesis-inhibiting effective amount of an oligonucleotide that antagonizes expression of a gene encoding an FGF receptor 4 (FGFR4) or antagonizes the level or functional activity of an expression product of the FGFR4 gene.