BICYCLIC COMPOUNDS AND THEIR USE AS ANTIBACTERIAL AGENTS AND BETALACTAMASE INHIBITORS

摘要

A compound of formula (I):;;wherein:
M is hydrogen or a pharmaceutically acceptable salt-forming cation;Y is OR1 or NR2R3,and R1, R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.

主权项

1. A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR1; R1 is a radical selected from the group consisting of: (1) C1-6 straight or branched chain alkyl which is optionally substituted; (2) C3-7 cycloalkyl which is optionally substituted; (3) C4-7 saturated heterocycles containing at least one heteroatom selected from O, N and S wherein the said heterocycle is optionally substituted, the ring S is optionally oxidized to S(O) or S(O)2 and the free ring N atom may optionally take a substituent; (4) Heterocyclyl (C1-6) alkyl wherein the said heterocycle has the same definition as defined in (3), and the said heterocycle is optionally substituted; (5) C5-7 membered saturated heterocycles optionally fused with a C3-7 membered cycloalkyl group to form a bicyclic ring system where the bicyclic ring system so formed is fused either through two adjacent carbon atoms or through a N atom shared by both the rings and the other end of the cycloalkyl chain is attached to the adjacent carbon atom of the molecule, each ring of the said bicyclic ring system independently optionally substituted; (6) C5-7 membered saturated heterocycles optionally fused with another C5-7 saturated heterocycle to form a bicyclic ring system where the bicyclic ring system so formed is fused either through two adjacent carbon atoms or through a N atom shared by both the rings, each ring of the said bi-cyclic ring system independently optionally substituted; (7) C3-7 cycloalkyl which is optionally fused with a C5-7 membered saturated heterocycle containing at least one heteroatom selected from O, N and S, the said bicyclic ring optionally substituted; (8) Bridged bicyclic ring system having optionally one or two heteroatoms selected from O, N and S, the bicyclic ring system optionally substituted either at the carbon atom or at the free N atom present in the ring; (9) C5-7 membered saturated heterocycles optionally fused with C5-7 membered heteroaryl ring where the bicyclic ring system so formed is fused either through two adjacent carbon atoms or through N atom shared by both the rings; (10) C5-7 membered saturated heterocycles optionally fused to a C3-6 membered ring system through a common carbon atom to form a spiro system optionally containing one heteroatom selected from O, N and S that is present in the spiro ring where the ring S is optionally oxidized to S(O) or S(O)2 and the free N atom present in either ring may optionally take a substituent; and (11) C5-7 membered heteroaryl (C1-6) alkyl which is optionally substituted, or a deuterated compound of any such compound.