| 发明名称 |
Method and Medicament for Inhibiting the Expression of a Given Gene |
| 摘要 |
The invention relates to an isolated RNA that mediates RNA interference of an mRNA to which it corresponds and a method of mediating RNA interference of mRNA of a gene in a cell or organism using the isolated RNA. |
| 申请公布号 |
US2014220113(A1) |
申请公布日期 |
2014.08.07 |
| 申请号 |
US201414218476 |
申请日期 |
2014.03.18 |
| 申请人 |
Alnylam Pharmaceuticals, Inc. |
发明人 |
Kreutzer Roland;Limmer Stefan |
| 分类号 |
C12N15/113 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising two oligoribonucleotides of double-stranded structure (dsRNAs), each dsRNA for inhibiting the expression of a distinct target gene in mammalian cells, wherein the two dsRNAs are capable of being introduced into the cell simultaneously, and wherein each dsRNA has 15 to 49 base pairs and has a complementary region I that is incorporated in the respective dsRNA. |
| 地址 |
Cambridge MA US |
