发明名称 |
PROCESS FOR PRODUCTION OF BENZYLOXYPYRROLIDINE DERIVATIVE, AND PROCESS FOR PRODUCTION OF HYDROCHLORIDE SALT POWDER OF OPTICALLY ACTIVE BENZYLOXYPYRROLIDINE DERIVATIVE |
摘要 |
<p>Provided are: a process for production of a benzyloxypyrrolidine derivative in high yield and safety, and a process for production of a hydrochloride powder of a benzyloxypyrrolidine derivative in high yield and safety; the process for production of a benzyloxypyrrolidine derivative expressed by the general formula (2) [Chemical formula 2], in reacting a pyrrolidinol derivative represented by the general formula (1) [Chemical formula 1 with a benzyl halide derivative in the presence of an alkali metal hydroxide, wherein the reaction is carried out in either of the following conditions A or B; condition A: an aprotic polar solvent, and condition B: an aliphatic ether solvent containing a phase transfer catalyst:</p> |
申请公布号 |
EP1950198(B1) |
申请公布日期 |
2014.08.06 |
申请号 |
EP20060822568 |
申请日期 |
2006.10.30 |
申请人 |
TORAY FINE CHEMICALS CO., LTD. |
发明人 |
MORIMOTO, MASAO;YAMAKAWA, ATSUSHI |
分类号 |
C07D207/12 |
主分类号 |
C07D207/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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