发明名称 |
FLUORESCENCE POLARIZATION HERG ASSAY |
摘要 |
<p>Disclosed are assays, methods, and kits for the screening of test compounds for their capability to induce cardiotoxicity in a subject. In particular, whether a test compound has the effect to prolong the Q-T interval as measured by an electrocardiogram in a human. The assays, methods, and kits disclosed herein make use of the binding interaction between novel fluorescent tracers and the hERG K+ channel, and the propensity of a test compound to influence that binding interaction.</p> |
申请公布号 |
EP2255201(B1) |
申请公布日期 |
2014.08.06 |
申请号 |
EP20090716003 |
申请日期 |
2009.02.27 |
申请人 |
LIFE TECHNOLOGIES CORPORATION |
发明人 |
PIPER, DAVID;VOGEL, KURT;SHEKHANI, MOHAMMED SALEH;HESS, STEPHEN;DUFF, STEVE;LIVELLI, THOMAS;ZHONG, ZHONG |
分类号 |
G01N33/58 |
主分类号 |
G01N33/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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