Composite material with properties of self-healing and release of active ingredients, for biomedical applications

摘要

This invention relates to a composite material for biomedical applications, in particular dental applications, which possesses self-healing capacity and is able to incorporate a system for the release of active ingredients at the stage of application and use.

主权项

1. A method of using a dental prosthesis or cement, comprising the step of contacting a dental prosthesis or cement with tissue in the mouth of a patient, wherein said dental prosthesis or cement comprises a self-healing composite material comprising:
a) a polymeric matrix; b) microspheres or nanospheres containing a polymerising agent; and c) a curing agent selected from the group consisting of diethylenetriamine, tetraethylenepentaneamine, tris(dimethyl-aminomethyl)-phenol, triethylenediamine, N,N-dimethylpiperidine,benzyldimethylamine, 2-(dimethylaminomethyl)phenol and 2-dimethylaminoethanol; wherein the polymerising agent of part (b) is selected from the group consisting of phenol-glycidyl ethers, glycidylamines, diglycidyl ether of bisphenol A, polyglycidyl ether of phenol-formaldehyde novolac, polyglycidylether of o-cresol-formaldehyde novolac, N, N, N′, N′-tetraglycidyl methylenedianiline, bisphenol A novolac, triglycidylether of trisphenol-methane, triglycidyl p-aminophenol,3,4-epoxycyclohexylmethyl-3,4-epoxycyclohexane carboxylate (EPC), 2,2-Bis[4-(2-hydroxy-3-methacryloxypropoxy)phenyl]propane (Bis-GMA), ethoxvlated Bis-GMA (EBPDMA), 1,6-bis-[4-(2-hydroxy-3-methacryloyloxypropyl)-phenyl]propane, ethyl-4-N,N-dimethylaminobenzoate (EDMAB), triethylene glycol dimethacrylate (TEGDMA), 1,6-bis-2-methacryloyloxy-ethoxycarbonylamino]-2,4,4-trimetylhexane (UDMA), dodecanediol dimethacrylate (D3MA), and fluorinated bis-GMA.