Methods for repressing B cell autoantibody secretion and for treating autoimmune disorders by administration of hematopoietic stem cells and macrophage-colony stimulating factor

摘要

The invention provides isolated regulatory immune cells as well as cell cultures and conditioned media derived therefrom. Also provided are methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders using regulatory immune cells or precursors thereto such as hematopoietic stem cells (HSC). The invention also provides methods of repressing B cell autoantibody production and/or secretion and methods of treating autoimmune disorders by administration of HSC and Macrophage-Colony Stimulating Factor (M-CSF). Further provided are methods of diagnosing in a mammalian subject a defect in regulatory cell mediated repression of autoantibody secretion by B cells.

主权项

1. A method of repressing B cell autoantibody secretion in a mammalian subject diagnosed with an autoimmune disorder, the method comprising:
administering a plurality of allogeneic hematopoietic stem cells (HSC) that can differentiate into dendritic cells and/or macrophages to the mammalian subject in an amount effective to repress B cell autoantibody secretion in the mammalian subject, and administering to the mammalian subject an agent that activates dendritic cells and/or macrophages through a Toll Like receptor (TLR), CD40 antigen and/or a TNF receptor to secrete a soluble factor that represses B cell autoantibody secretion.