Self-assembling high density ordered patterned biomolecule array and method for making and using the same

摘要

A method for fabricating a universal substrate for attaching biomolecules, including sequencing features and the resulting substrate. A method of direct detection of analytes utilizes a Complementary Metal Oxide Semiconductor (CMOS) sensor with the substrate.

主权项

1. A patterned substrate comprising a substrate comprising a plurality of first regions and a second region wherein:
the plurality of first regions have a density on the substrate between 5×106 and 25×106/mm2 and an associated biomolecule specifically located at each of said plurality of first regions and a complementary metal-oxide semiconductor (CMOS) sensor specifically located at each of said plurality of first regions.