| 主权项 |
1. A trispecific or tetraspecific antibody, comprising:
a) a light chain comprising a light chain variable domain VL and a light chain constant domain CL, and a heavy chain comprising a heavy chain variable domain VH and heavy chain constant domains CH1, CH2, and CH3, wherein the light chain and the heavy chain specifically bind to a first antigen; and b) a modified light chain and a modified heavy chain that specifically bind to a second antigen, wherein: (i) the modified light chain comprises in N-terminal to C-terminal direction VL, CH1, and the modified heavy chain comprises in N-terminal to C-terminal direction VH, CL, CH2, and CH3; (ii) the modified light chain comprises in N-terminal to C-terminal direction VH, CL, and the modified heavy chain comprises in N-terminal to C-terminal direction VL, CH1, CH2, and CH3; or (iii) the modified light chain comprises in N-terminal to C-terminal direction VH, CH1, and the modified heavy chain comprises in N-terminal to C-terminal direction VL, CL, CH2, and CH3; and c) one to four antigen binding peptides fused via a peptide connector to the C- or N-terminus of the light chains or heavy chains of a) and/or b) wherein said antigen binding peptides specifically bind one or two further antigens. |
