发明名称 |
Method of using β-hydroxy-β-methylbutyrate to treat a condition |
摘要 |
Disclosed are methods of treating an individual having a condition characterized by an imbalance in type 1 and type 2 cytokine production, wherein the method comprises administering to the individual an amount of β-hydroxy-β-methylbutyrate (HMB) effective to modulate or otherwise cause an increase in the ratio of type 1 to type 2 cytokines, including an increase in the ratio of type 1 to type 2 cytokines without a corresponding increase in type 2 cytokine levels. Also disclosed are methods of using HMB to treat asthma and allergies. The methods of the present invention are based upon the discovery that HMB modulates cytokine production, most typically by increasing type 1 cytokines without a corresponding increase in type 2 cytokines. |
申请公布号 |
US8796333(B2) |
申请公布日期 |
2014.08.05 |
申请号 |
US201213347750 |
申请日期 |
2012.01.11 |
申请人 |
Abbott Laboratories |
发明人 |
Thomas Debra L.;Mukerji Pradip |
分类号 |
A61K31/191;A61K31/19 |
主分类号 |
A61K31/191 |
代理机构 |
Calfee, Halter & Griswold LLP |
代理人 |
Calfee, Halter & Griswold LLP |
主权项 |
1. A method of treating an individual having a condition characterized by a higher relative ratio of type 2 cytokines to type 1 cytokines, the method comprising administering to the individual a composition comprising an effective amount of β-hydroxy-β-methylbutyrate to increase the relative ratio of type 1 to type 2 cytokines, wherein said treating consists of at least one of delaying the onset of said condition and reducing the severity of symptoms of said condition, and wherein said condition is selected from the group consisting of allergy and asthma. |
地址 |
Abbott Park IL US |