Modulators of cystic fibrosis transmembrane conductance regulator

摘要

This invention relates to a compound of Formula I:;
or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH2OH.

主权项

1. A method of treating or lessening the severity of a disease in a patient, wherein said disease is selected from cystic fibrosis, smoke induced COPD, pancreatitis, pancreatic insufficiency, hereditary emphysema, COPD, or dry-eye disease, said method comprising administering to said patient an effective amount of a compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein R is COOH or CH2OH.