Methods for preparing purified lipopeptides

摘要

The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention also relates to pharmaceutical compositions comprising the purified form of the lipopeptide and methods of using these compositions.

主权项

1. A composition comprising a crystalline form of a calcium salt of daptomycin, having an X-ray powder diffraction pattern, using a Cu (λ=1.54 Å) x-ray source, with peaks expressed in degrees 2Θ at angles of about 10.9°, about 19.2° and about 23.3°, or at angles of about 19.2°, about 23.2°, about 23.4° and about 23.6°.