Pre-or post-exposure treatment for filovirus or arenavirus infection

摘要

The compositions and methods of the invention described herein provide pre- or post-exposure treatments against filovirus or arenavirus infection by expressing one or more genes (e.g., two ore more genes) from filoviruses or arenaviruses in a delivery vehicle (e.g., a recombinant viral vector or a liposome).

主权项

1. A method of inhibiting or treating infection by Sudan species of Ebola virus (SEBOV) in a subject exposed to said SEBOV, said method comprising administering to said subject no later than 30 minutes after infection by said SEBOV a pharmaceutical composition comprising a recombinant viral vector that encodes at least a glycoprotein from said SEBOV, wherein the glycoprotein is heterologous to the viral vector.