System, method, and computer software code for predicting an acute hypotensive episode

摘要

A system for determining onset of an acute hypotensive episode, the system includes a plurality of collectors configured to determine heart rate, mean arterial pressure, stroke volume, total peripheral resistance, and/or age of a patient, an estimate model configured to receive data from the collectors, a simulate model configured to receive information from the estimate model to simulate operation of an effector portion and a neural portion of an arterial baroreceptor reflex pathway, and a prediction model configured predict onset of an acute hypotensive episode based on results from the simulate model. A method and a computer software code for determining onset of an acute hypotensive episode are also disclosed.

主权项

1. A method for determining onset of an acute hypotensive episode, the method comprising:
determining heart rate and mean arterial pressure of a patient at a given time using one or more sensors coupled to the patient; estimating, using at least one processor, an onset of an acute hypotensive episode based on the measured heart rate and mean arterial pressure at the given time in association with heart rate and mean arterial pressure time-series data prior to the given time within a predetermined period; simulating, using the processor, an evolution of mean arterial pressure based on a mathematical model of a neural portion of an arterial baroreceptor reflex pathway for a predetermined prediction period and further based on a number of repetitive runs, wherein the neural portion parameters are random coefficients of a linear system described as an nth order differential equation with random coefficients calculated via a maximum likelihood estimator using past read heart rate and mean arterial pressure of the patient over a predetermined estimation period; predicting, using the processor, the acute hypotensive episode based on results from simulating the onset of the acute hypotensive episode; and reporting, using the processor, the predicted acute hypotensive episode.