Devices and methods for the regeneration of bony defects

摘要

This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process. The method of surface treatment allows for the manufacture of a suitable implantable composite while retaining the unique osteostimulative properties that are associated with bioactive glass particles.

主权项

1. A bone regenerative implantable composition comprising from about 2% to about 20% by weight of a bioresorbable polymer and from about 10% up to about 98% bioactive glass particles that have been pre-reacted with a buffer, and wherein the surface ionic reactivity of the bioactive glass is reduced as compared to non-prereacted bioactive glass.