Multiphoton in vivo flow cytometry method and device

摘要

The invention relates to a method for diagnosing a disease state mediated by pathogenic cells, said method comprising the steps of administering to a patient a composition comprising a conjugate or complex of the general formula
Ab-Xwherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and detecting the pathogenic cells that express a receptor for the ligand using mutiphoton in vivo flow cytometry.

主权项

1. A method of diagnosing a disease state mediated by pathogenic cells comprising the step of
administering to a patient a composition comprising a conjugate or complex of the general formula
Ab-X wherein the group Ab comprises a ligand that binds to the pathogenic cells and the group X comprises an imaging agent, and wherein the pathogenic cells express a receptor for the ligand and are detected using multiphoton in vivo flow cytometry wherein the disease state mediated by the pathogenic cells is diagnosed by detecting the conjugate bound to at least one of the pathogenic cells.