| 主权项 |
1. A method of treating pulmonary hypertension, glaucoma, neuronal degeneration or Alzheimer's disease in a patient comprising administering to said patient an effective amount of at least one compound of the formulae (I) or (I′):wherein
R1 is H; R2 is H; R3 is H; R4 is H, halogen, OH, CN, (C1-C6)alkyl; R5 is H, halogen, CN, NO2, (C1-C6)alkyl, (C2-C6)alkenyl, —NH2, NH—SO2H, NH—SO2—(C1-C6)alkyl, NH—C(O)—(C1-C6)alkyl, C(O)N[(C1-C6)alkyl]2, C(O)OH or C(O)O—(C1-C6)alkyl; R6 and R6′ are independently of each other H, R′, (C1-C8)alkyl, (C1-C6)alkylene-R′, (C1-C6)alkylene-O—(C1-C6)alkyl, (C1-C6)alkylene-O—R′, (C1-C6)alkylene-CH[R′]2, (C1-C6)alkylene-C(O)—R′, (C1-C6)alkylene-C(O)NH2, (C1-C6)alkylene-C(O)NH—R′, or (C1-C6)alkylene-C(O)N[R′]2; R7 and R8 are independently of each other H, halogen, CN, NO2, (C1-C6)alkyl, O—(C1-C6)alkyl, (C2-C6)alkenyl, NH2, NH—SO2H, NH—SO2—(C1-C6)alkyl, SO2—NH2, NH—C(O)—(C1-C6)alkyl, C(O)N[(C1-C6)alkyl]2, C(O)OH, or C(O)O—(C1-C6)alkyl; R9 is halogen or (C1-C6)alkyl; R′ is (C3-C8)cycloalkyl, (C5-C10)heterocyclyl or (C6-C10)aryl; n is 0; and L is O or O—(C1-C6)alkylene; wherein in residues R4, R5, R7 and R8 one alkyl or alkylene hydrogen atom can optionally be substituted by OH, OCH3, COOH, COOCH3, NH2, NHCH3, N(CH3)2, CONH2, CONHCH3 or CON(CH3)2, or a pharmaceutically acceptable salt thereof, or a stereoisomeric form thereof, or a pharmaceutically acceptable salt of a stereoisomeric form thereof. |
