Regulation of immune responses by modulation of the function of antigen presenting cells

摘要

The present invention relates to the use of chaperonin 10 to modulate the function of antigen presenting cells. More particularly the invention resides in the modulation of cell surface expression of MHC molecules such as HLA.

主权项

1. A method for treating a disease or condition selected from the group consisting of an autoimmune disorder, allergy, and asthma in a subject by modulating cell surface expression of at least one MHC molecule, wherein the method consists essentially of administering to the subject an effective amount of chaperonin 10, wherein the effective amount is about 0.01 mg to about 500 mg per kg body weight per 24 hours, thereby to treat the disease or condition selected from the group consisting of an autoimmune disorder, allergy, and asthma, wherein the chaperonin 10 is a human chaperonin 10 selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3.