发明名称 |
Mutant-selective EGFR inhibitors and uses thereof |
摘要 |
The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same. |
申请公布号 |
US8796255(B2) |
申请公布日期 |
2014.08.05 |
申请号 |
US201113291706 |
申请日期 |
2011.11.08 |
申请人 |
Celgene Avilomics Research, Inc |
发明人 |
Lee Kwangho;Niu Deqiang;Baevsky Matthew F. |
分类号 |
A61K31/495;A61K31/505;C07D239/02 |
主分类号 |
A61K31/495 |
代理机构 |
Choate, Hall & Stewart LLP |
代理人 |
Reid Andrea L. C.;Buteau Kristen C.;Choate, Hall & Stewart LLP |
主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
R1 is —CF3 or —Cl; W is —O— or —NH—; R2 is —R or R3 is —R, —C(O)R, or —C(O)OR; and each R is independently C1-4 alkyl or C1-4 fluoroalkyl. |
地址 |
Bedford MA US |