发明名称 Mutant-selective EGFR inhibitors and uses thereof
摘要 The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.
申请公布号 US8796255(B2) 申请公布日期 2014.08.05
申请号 US201113291706 申请日期 2011.11.08
申请人 Celgene Avilomics Research, Inc 发明人 Lee Kwangho;Niu Deqiang;Baevsky Matthew F.
分类号 A61K31/495;A61K31/505;C07D239/02 主分类号 A61K31/495
代理机构 Choate, Hall & Stewart LLP 代理人 Reid Andrea L. C.;Buteau Kristen C.;Choate, Hall & Stewart LLP
主权项 1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein: R1 is —CF3 or —Cl; W is —O— or —NH—; R2 is —R or R3 is —R, —C(O)R, or —C(O)OR; and each R is independently C1-4 alkyl or C1-4 fluoroalkyl.
地址 Bedford MA US