| 主权项 |
1. A method for treating endometriosis comprising administering to a patient in need thereof a compound having the structure of formula (I) or a pharmaceutically acceptable salt thereof:wherein
X is S or Se; W is O, S, or (R)(R), where each occurrence of R is independently H or C1-2alkyl; n is 0, 1 or an integer from 2 to 20; R1 and R2 are each independently C1-10alkyl; R3 is H, C1-10alkyl, or C0-6alkyl-COOR6; R3′ is H, amino, cyano, halogen, aryl, aralkyl, heteroaryl, heteroaralkyl, carboxyl, C1-10alkyl, C1-10alkenyl, or C1-10alkynyl; R4 is —OH, —H, —CH3, amino, —OC(O)C1-10aralkyl, —OC(O)C1-10alkyl, —OC(O)aryl, or a glutamine substituent; and R5 is —OH, cyano, C1-6alkoxy, amino, O—C1-10alkyl, O-aralkyl, —OC(O)C1-10aralkyl, —OC(O)C1-10alkyl, —OC(O)aryl, or a glycine substituent; and R6 is H or C1-10alkyl; or a compound having a structure of formula (III) or a pharmaceutically acceptable salt thereofwherein
X is S or Se; W is O, S, or (R)(R), where each occurrence of R is independently H or a C1-2alkyl; Z is CH or N; R1 and R2 are independently C1-10alkyl, preferably R1 and R2 are independently selected from methyl, ethyl, propyl, and isopropyl; and R5 is —OH, cyano, C1-10alkoxy, amino, O-aralkyl, O-aralkyl, —OC(O)C1-10aralkyl, —OC(O)C1-10alkyl, —OC(O)aryl, or a glycine substituent; R6 is H or C1-10alkyl; R7 is selected from halogen, —OH, C0-6alkyl-COOR6, C1-6alkyl, C1-6alkoxy, amino, amido, cyano, and nitro; m is an integer from 0 to 4. |
