主权项 |
1. A pharmaceutical composition which inhibits chemoattractant receptor-homologous molecule expressed on T-helper 2 cell activity comprising a pharmaceutically acceptable carrier, diluent or excipient and a compound according to Formula (I), or stereoisomers, tautomers and pharmaceutically acceptable salts thereof, wherein: A is selected from the group consisting of: where n is 0, 1, 2, 3 or 4; m is 2; B is selected from the group consisting of phenyl or piperazinyl; R1 is hydrogen; R2 is phenyl, wherein R2 is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, C1-C6-alkyl; R3 is selected from the group consisting of C1-C6-alkyl, aryl, heteroaryl, C1-C6-alkylaryl, C1-C6-alkylheteroaryl, C3-C8-cycloalkyl and C3-C8-heterocycloalkyl wherein each of said C1-C6-alkyl, aryl, heteroaryl, C1-C6-alkylaryl, C1-C6-alkylheteroaryl, C3-C8-cycloalkyl and C3-C8-heterocycloalkyl is optionally substituted with one or more substituents selected from the group consisting of halogen, cyano, C1-C6-alkyl, C1-C6-alkoxy, heteroaryl, aryl, thioalkoxy and thioalkyl, or wherein said aryl, heteroaryl, C1-C6-alkylaryl, C1-C6-alkylheteroaryl, C3-C8-cycloalkyl or C3-C8-heterocycloalkyl may be fused to one or more aryl, heteroaryl, C3-C8-cycloalkyl or C3-C8-heterocycloalkyl groups and may be substituted with one or more substituents selected of the group consisting of C1-C6-alkyl, alkoxy, aryl, heteroaryl, carboxyl, cyano, halogen, hydroxy, amino, aminocarbonyl, nitro, sulfoxy, sulfonyl, sulfonamide and trihaloalkyl; R7 is selected from the group consisting of hydrogen, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, aryl, heteroaryl, C3-C8-cycloalkyl, C3-C8-heterocycloalkyl, carboxy, cyano, amino and hydroxy; the aryl is selected from phenyl or naphthyl; and the heteroaryl is selected from pyridyl, indolyl, benzimidazolyl and quinolyl. |