| 发明名称 | Dengue serotype 2 attenuated strain | ||
| 摘要 | The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain. | ||
| 申请公布号 | US8795688(B2) | 申请公布日期 | 2014.08.05 |
| 申请号 | US201113281255 | 申请日期 | 2011.10.25 |
| 申请人 | Sanofi Pasteur;Centers for Disease Control and Prevention | 发明人 | Kinney Richard;Kinney Claire Y. H.;Barban Véronique;Lang Jean;Guy Bruno |
| 分类号 | A61K39/12;C12N7/00;C12N7/08 | 主分类号 | A61K39/12 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP |
| 主权项 | 1. A fragment of a polyprotein encoded by SEQ ID NO: 1, wherein the fragment comprises envelope (E) protein which comprises a glutamic acid at position 228 of the E protein. | ||
| 地址 | Lyons FR | ||