发明名称 |
Nucleic acids encoding inactive variants of human telomerase |
摘要 |
The invention provides compositions and methods related to human telomerase reverse transcriptase (hTRT), the catalytic protein subunit of human telomerase. Catalytically inactive variants comprising deletions or other mutations are provided. |
申请公布号 |
US8796438(B2) |
申请公布日期 |
2014.08.05 |
申请号 |
US200611504402 |
申请日期 |
2006.08.14 |
申请人 |
Geron Corporation;The Regents of the University of Colorado |
发明人 |
Morin Gregg B. |
分类号 |
A61K38/00 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
Mooi Leslie A. |
主权项 |
1. An isolated nucleic acid that encodes a polypeptide having at least 90% sequence identity to SEQ ID NO:2 and wherein said polypeptide comprises one or more deletions selected from the group consisting of:
a) all of amino acid residues 930-934; b) at least 10 consecutive amino acids from residues 637-660; c) at least 10 consecutive amino acids from residues 748-766; d) at least 10 consecutive amino acids from residues 1055-1071; and e) at least 10 consecutive amino acids from residues 1084-1116;wherein said polypeptide lacks processive telomerase enzyme activityand wherein said polypeptide inhibits telomerase catalytic activity when expressed in a cell expressing human telomerase reverse transcriptase (hTRT) and human telomerase RNA component. |
地址 |
Menlo Park CA US |