ACTH prophylactic treatment of renal disorders

摘要

Provided herein are methods for prophylactic treatment of renal disorders comprising administration of adrenocorticotropic hormone (ACTH), or fragment, analog, complex or aggregate thereof, or any combination thereof, to an individual suspected of having, predisposed to, or at risk of developing a renal disorder.

主权项

1. A method of prophylactically treating acute kidney injury (AKI) in an individual in need thereof comprising selecting an individual suspected of having, predisposed to, or at risk of developing acute kidney injury and administering an adrenocorticotropic hormone (ACTH) peptide to the individual in need thereof, wherein the ACTH peptide is administered as a first dose and one or more subsequent doses; and
wherein the ACTH peptide is selected from the group consisting of:(a) the ACTH1-39 peptide consisting of the sequence:(SEQ ID NO: 1)H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-   1   2   3   4   5   6   7   8   9  10Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-11  12  13  14  15  16  17  18  19  20Lys-Val-Tyr-Pro-Asp-Gly-Ala-Glu-Asp-Gln-21  22  23  24  25  26  27  28  29  30Leu-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH;31  32  33  34  35  36  37  38  39(b) the ACTH1-24 peptide consisting of the sequence:(SEQ ID NO: 2)H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-   1   2   3   4   5   6   7   8   9  10Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-11  12  13  14  15  16  17  18  19  20Lys-Val-Tyr-Pro; and21  22  23  24(c) the ACTH peptide is ACTH1-17 peptide consisting of the sequence of:(SEQ ID NO: 3)H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-   1   2   3   4   5   6   7   8   9  10Lys-Pro-Val-Gly-Lys-Lys-Arg.11  12  13  14  15  16  17