CaSR agonists

摘要

By searching various kinds of compounds having CaSR agonistic activity, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise the compound. More specifically, the present invention provides CaSR agonistic agents, pharmaceutical compositions, preventive or therapeutic agents for diarrhea and kokumi-imparting agents each of which comprise a glutamic acid derivative having CaSR agonistic activity or pharmaceutically acceptable salts thereof.

主权项

1. A glutamic acid derivative of formula (I) or a pharmaceutically acceptable thereof: wherein R1 and R3-R5 are each independently selected from the group consisting of a hydrogen atom, a halogeno group, a hydroxyl group, a nitro group, —NH2, an optionally substituted alkyl group having 1 to 6 carbon atoms, and an optionally substituted alkoxy group having 1 to 6 carbon atoms; R2 is selected from the group consisting of a nitro group, a sulfonic acid group, R6 is a hydroxyl group; R7 is a hydrogen atom or an optionally substituted alkyl group having 1 to 6 carbon atoms; and X is a methylene group or an oxygen atom.