| 发明名称 | Pharmaceutical compositions providing enhanced drug concentrations | ||
| 摘要 | A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer. | ||
| 申请公布号 | US8796341(B2) | 申请公布日期 | 2014.08.05 |
| 申请号 | US201313915311 | 申请日期 | 2013.06.11 |
| 申请人 | Bend Research, Inc. | 发明人 | Curatolo William J.;Shanker Ravi M.;Babcock Walter C.;Friesen Dwayne T.;Nightingale James A. S.;Lorenz Douglas A. |
| 分类号 | A61K47/32;A61K47/00;A61K9/14 | 主分类号 | A61K47/32 |
| 代理机构 | Klarquist Sparkman, LLP | 代理人 | Klarquist Sparkman, LLP |
| 主权项 | 1. A composition comprising: (a) a drug in a pharmaceutically acceptable solubility-improved form that is a suspension of said drug suspended in a liquid at a concentration that is at least 10-fold the equilibrium concentration of said drug in a use environment; and (b) an amphiphilic concentration-enhancing polymer;wherein said drug alone has an aqueous solubility of up to 2 mg/mL at pH 1 to 8. | ||
| 地址 | Bend OR US | ||