9, 10-secopregnane derivative and pharmaceutical

摘要

A main object of the invention is to provide a novel useful vitamin D3 derivative, which has an excellent vitamin D3 activity and, as compared with conventional vitamin D3 derivatives, has a relatively small amount of influence on the systemic calcium metabolism. The invention includes a 9,10-secopregnane derivative of the following general formula [1] and a pharmaceutical composition containing it as active ingredient.;
In the general formula [1], the following partial structure between the 16-position and the 17-position means a single bond or a double bond:
;
Y is a single bond, an alkylene, an alkenylene or phenylene; R1 and R2 are the same or different, each represents hydrogen, an alkyl or a cycloalkyl; or R1 and R2, taken together with the adjacent carbon atom, form a cycloalkyl; R3 is hydrogen or methyl; Z is hydrogen, hydroxy or —NR11R12.

主权项

1. A 9,10-secopregnane compound of formula [1]: wherein the following partial structure between the 16-position and the 17-position means a single bond or a double bond: Z is hydroxy, Y is ethylene or ethenylene, R1 and R2 are the same or different, each is methyl, trifluoromethyl or ethyl, and R3 is methyl: Ra and Rb are both hydrogens, or Ra and Rb, taken together, form methylene; Rc and Rd are the same or different, and each represents hydrogen or methyl, or Re and Rd, taken together, form methylene: or a pharmaceutically acceptable salt thereof.