| 发明名称 | Tissue repair with multipotent cells | ||
| 摘要 | The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells. The invention further relates to a kit for carrying out the method for repairing a tissue defect. | ||
| 申请公布号 | US8796019(B2) | 申请公布日期 | 2014.08.05 |
| 申请号 | US201113220552 | 申请日期 | 2011.08.29 |
| 申请人 | CellCoTec B.V. | 发明人 | Hendriks Jeanine Anna Alphonse;De Bruijn Mark Ewart;Riesle Jens Uwe |
| 分类号 | C12N5/00;C12N5/02 | 主分类号 | C12N5/00 |
| 代理机构 | Morrison & Foerster LLP | 代理人 | Morrison & Foerster LLP |
| 主权项 | 1. A method for repairing a tissue defect in a human or animal patient comprising (a) taking a biopsy comprising a population of multipotent cells selected from the group consisting of stem cells, mesenchymal stem cells and bone marrow cells; (b) taking a biopsy comprising a population of primary cells selected from the group consisting of chondrocytes, cardiomyocytes and myocytes; (c) combining the population of multipotent cells and the population of primary cells wherein the ratio of the number of cells in the population of primary cells to the number of cells in the population of multipotent cells is from 1:200 to 1:3; and (d) applying the combined populations of multipotent cells and primary cells to the tissue defect. | ||
| 地址 | Bilthoven NL | ||