| 发明名称 |
Oligomer-corticosteroid conjugates |
| 摘要 |
The invention provides corticosteroids that are chemically modified by covalent attachment of a water soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits a reduced biological membrane crossing rate as compared to the biological membrane crossing rate of the corticosteroid not attached to the water soluble oligomer. |
| 申请公布号 |
US8796248(B2) |
申请公布日期 |
2014.08.05 |
| 申请号 |
US200812680877 |
申请日期 |
2008.10.03 |
| 申请人 |
Nektar Therapeutics |
发明人 |
Zhang Wen;Riggs-Sauthier Jennifer;Harris J. Milton;Bentley Michael D. |
| 分类号 |
A61K31/573;C07J41/00;C07J5/00;A61P25/08 |
主分类号 |
A61K31/573 |
| 代理机构 |
|
代理人 |
Marquart Timothy A.;Wilson Mark A. |
| 主权项 |
1. A compound comprising a corticosteroid residue covalently attached via a releasable linkage to a water-soluble, non-peptidic oligomer, wherein the compound is selected from a compound of the formula: wherein POLY is a water-soluble, non peptidic oligomer having a number of repeating monomers in the range of from 2 to 30. |
| 地址 |
San Francisco CA US |
