NOVEL HETEROCYCLIC COMPOUNDS AND USE THEREOF

摘要

The present invention relates to a novel compound represented by chemical formula 1 below, or a pharmaceutically acceptable salt thereof; to a preparation method of the novel compound; and to a pharmaceutical composition comprising the novel compound or a pharmaceutically acceptable salt thereof as an active ingredient to prevent or treat IL-6-mediated diseases, and a health functional food comprising the novel compound or a pharmaceutically acceptable salt thereof as an active ingredient to prevent or alleviate IL-6-mediated diseases. Novel sulfur-linked heterocyclic compounds in the present invention are small molecules. Therefore, when the heterocyclic compounds are used for a therapeutic agent, the heterocyclic compounds do not cause immune response, and simultaneously inhibits the transcription activity and phosphorylation of STAT3 which is an inflammation-related transcription factor activated by IL-6. Accordingly, the heterocyclic compounds can widely be used for the development of a preventive or therapeutic agent for IL-6-mediated diseases.