POLYMERIC NANOPARTICLES FOR DRUG DELIVERY

摘要

Disclosed are nanoparticles comprising a block copolymer and optionally one or more active agent(s), compositions comprising said nanoparticles and methods of preparing said nanoparticles. The block copolymer comprises blocks (i) a first polymer that is a polyester or polyamide and (ii) a second polymer comprising a hydrocarbon chain containing ester or ether bonds with hydroxyl number ≧10. The active agent(s) may be present within the nanoparticles or on the surfaces of the nanoparticles. The nanoparticles may optionally be associated with a surface-modifying moiety such that they are useful as drug delivery and molecular imaging devices. The surface-modifying moiety may target the nanoparticles to a desired target, cell, tissue or biomarker.

主权项

1. A nanoparticle comprising a block copolymer
comprising blocks A and D, wherein block A comprises a first polymer comprising monomer units B and C, wherein B is an aliphatic dicarboxylic acid wherein the total number of carbon atoms is ≦30 and C is a dihydroxy or diamino monomer, and wherein block D comprises a second polymer comprising a hydrocarbon chain containing ester or ether bonds with hydroxyl number ≧10.